UM’s AI tools help guide liver treatment
University of Macau (UM) researchers have developed an artificial intelligence (AI) tool that identifies an aggressive liver cancer subtype from routine pathology slides, potentially accelerating precision treatment, UM recently announced. Led by Associate Professor Joong Sup Shim, the international team at UM found that about 14.6% of hepatocellular carcinoma patients have complete RB1 gene loss. These patients face a 3.32-fold higher risk of death, yet their tumors responded strongly to combined mitotic and PARP inhibitors in laboratory and animal studies. The institution highlights that the findings, published in “Signal Transduction and Targeted Therapy,” could help clinicians quickly identify high-risk patients and tailor therapy without costly genomic sequencing.
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